TMU/TMS

TMS ÇÖZÜMLERİ

  • Fonksiyonel Tanı
    Fonksiyonel Tanı

    #TMS  #PAIRED MS  #SICI  #LICI  #ICI

  • Nörorehabilitasyon
    Nörorehabilitasyon

    #TMS  #RTMS  #UP to 10Hz  #Up to 100Hz

  • Majör Depresif Bozukluk Tedavisi
    Majör Depresif Bozukluk Tedavisi
  • Pediatri
    Pediatri

    #TMS  #RTMS  #UP to 10Hz  #Up to 100Hz

  • Çevresel Manyetik Uyarma
    Çevresel Manyetik Uyarma

    #TMS  #RTMS  #UP to 10Hz

  • Üroloji ve Jinekoloji
    Üroloji ve Jinekoloji

    #TMS  #RTMS  #UP to 10Hz

  • TMS-EEG
    TMS-EEG

    #EEG    #EP    #TMS

Neuro-MS/D

Advanced Terapeutic

Tanı, Tedavi ve Araştırma amaçlı kullanılan Transkraniyel Manyetik Stimülatör Serisi

usb USB Bağlantı
iso ISO Belgelendirme

 

Coil Çeşitleri 

Şekil olarak: ring, figure-of-eight, angulated figure-of-eight
Soğutma Yöntemi : Yağ soğutmalı ve Hava soğutmalı

 

  • Peak magnetic field — up to 4 Tesla
  • Number of pulses generated during one session — up to 10 000
  • Several delivery set variants
  • Cooling unit and expansion unit can be included in the delivery set optionally
  • Above standard coils Neurosoft company develops customs coils according to customers requests: animal coils, air cooled coils, specially shaped coils.
  • Pulse waveform: monophasic, biphasic, theta-burst (TBS), paired stimulation
  • 2-channel digital EMG system for motor response threshold acquisition
  • Neuro-MS.NET software for magnetic stimulator control
  • Set of different coils (non-cooled, cooled, placebo)
  • "Delayed charging" mode
  • Multistage system of device protection
  • Connection to computer via USB port

Coils

The stimulator can be equipped with a wide range of cooled and non-cooled stimulating coils of different shape and size: ring, figure-of-eight, angulated figure-of-eight. For research purposes a device can be supplied with placebo coils. Above standard coils Neurosoft Company develops coils according to customer requests: animal, air-cooled and specially shaped ones.

Modular Construction

New version of magnetic stimulator consists of several separate units, thus you can select the configuration required for you. We offer you several ready-made configuration variants that can be most conveniently applied for the practical use.

 
Main Unit

Main unit is the basis of any configuration. The main stimulator unit is intended for stimulator operation control and can be used as an independent device (if it is equipped with coils). The front panel contains digital indicators displaying all parameters of stimulator operation and controls used to adjust stimulation parameters.

 
Cooling Unit

One of the problems of magnetic stimulator application is quick overheating of coils during the stimulation performing. In Neuro-MS/D this problem is solved with the use of special cooling unit and cooled coils. In fact, this is a tank with the cooling liquid, the pump running the cooling liquid through the coil and the fridge. The unit allows increasing continuous operation time up to 10 000 pulses without overheating. Actually, it means that stimulator can operate for a long time without overheating. 

Expansion Unit

The expansion unit allows increasing the stimulation intensity by 40% and also perform paired and monophasic stimulation.

 
 
Extra Power Supply Unit

The main unit of the magnetic stimulator allows operating with up to 30 Hz frequency. However, the stimulator does not generate the maximal induction at 30 Hz frequency. It can be achieved only at 5 Hz (or less) frequency. Also there is a term “maximal effective stimulation frequency”. This term indicates the frequency at which transcranial magnetic stimulation can be performed and each pulse in series is higher than motor threshold for most people. For main unit it equals 10 Hz. The extra power supply unit makes it possible to increase this frequency twice (up to 20 Hz).

 

Neuro-EMG-MS is a Special Device to Record Motor Evoked Potentials

This device is EMG amplifier. If you connect it to computer, you can record the motor evoked potentials obtained at TMS stimulation of motor areas of cerebral cortex and peripheral nervous system. When you record the motor evoked potentials, you can define the so called motor threshold (MT). This is a very important parameter. As far the stimulation amplitude at performing of treatment procedures is often set relative to obtained MT.

 

 

Neuro-MS.NET Software

The delivery set includes the special software for magnetic stimulator control with the use of computer. This software allows keeping the patient database, detecting motor response threshold, controlling the stimulation courses and sessions. A user can perform the stimulation according to already specified stimulation programs and also create own ones or edit the available stimulation programs.

 

 

New Coil Holder

Now Neuro-MS/D delivery set (research variant) includes FISSO holder to fix the magnetic stimulator coil. It very convenient as it can be fixed in any position by rotating one screw. You can order this coil holder for other delivery set variants.

 

 

Specialized Computer

The device can be both equipped with common computer and specialized one with touchscreen interface. Neuro-MS.NET is specially adapted finger-controlled software. It allows controlling the magnetic stimulator operation quickly and conveniently.

 

Operation with Any Neurophysiological Equipment

Neuro-MS/D  magnetic stimulator can operate jointly with neurophysiological equipment manufactured by Neurosoft Ltd. and also digital EMG systems of third-party manufacturers. To connect to EMG systems of third-party manufacturers, the trigger socket is provided. The special trigger unit can also be applied to adjust the trigger pulse parameters.

 

 

 

 
 
 
 
 
 
 
 

 

Advanced Therapeutic Variant

The principle of therapeutic magnetic stimulation is based on the following. The magnetic stimulator uses the magnetic pulses of short duration and emerging high-intensity electromagnetic field easily penetrates through clothes, cranium bones and soft tissues. They exert influence upon deep nerve centers, peripheral nerves, cerebral and spinal cord, which are inaccessible for other kinds of stimulation.

dd3The distinctive feature of Neuro-MS/D device is possibility to perform transcranial magnetic stimulation (TMS). However, the well-known problem is quick coil overheating.

The cooling unit included in therapeutic delivery set variant allows performing long-term therapeutic impacts (also transcranial magnetic stimulation with high frequency and intensity) without coil overheating.

Advanced therapeutic variant provides the possibility to increase the so called maximal effective stimulation frequency (the frequency when each stimulus in series has 100% intensity of motor threshold for most people) twice (up to 20 Hz) owing to extra power supply unit.

Most often these stimulator variants are used to treat depressions (including severe and drug-resistant), tinnitus. Besides, there are positive and encouraging results obtained at rehabilitation of stroke patients.

Neuro-MS/D (Therapeutic) Applications:

Neurology:

  • treatment of central and peripheral nervous system disorders: vascular and vertegragenic pathologies, consequences of stroke, neuropathies, demyelinating disorders of nervous system, spinocerebellar degeneration, spasticity, pain syndrome, radiculopathies, hemicrania, Alzheimer‘s disease

Ophthalmology:

  • partial atrophy of visual nerve owing to different etiology

Psychiatry:

  • treatment of depressions, schizophrenia, obsessive-compulsive disorders, manias and other psychiatric disorders

The delivery set of therapeutic variant includes Neuro-MS.NET software allowing to program any stimulation algorithms. It also provides theta-burst mode with up to 100 Hz stimulation frequency.

In case the therapeutic variant is equipped with neurophysiological equipment, it will receive all capabilities of diagnostic variant.

Examples of Techniques**

** screenshots of Neuro-MEP.NET software which is supplied optionally

tms ss1b 1 thumb tms ss2b 1 thumb tms ss3b 1 thumb tms ss4b 1 thumb
 Study of root conduction time  Tripple stimulation test  Study of central motor conduction time  Motor response variability

 

If you want to know more about the magnetic stimulation, we recommend reading the following literature:

  • Marcolin M.A., Padberg F. Transcranial Brain Stimulation for Treatment of Psychiatric Disorders
  • Hallett M., Chokroverty S. Magnetic Stimulation in Clinical Neurophysiology
  • Wassermann E.M., Epstein C.M., Ziemann U., Walsh V., Paus T., Lisanby S.H. The Oxford Handbook of Transcranial Stimulation
  • Edited by Judit Málly M. D., Ph. D., Habil. Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment and Rehabilitation of Central Nervous Diseases
  • Moacyr Alexandro Rosa, Marina Odebrecht Rosa Transcranial magnetic stimulation

tms picb 1 bigTMS Use to Make Prognosis for Rehabilitation of Stroke Patients

The magnetic stimulator can be successfully used to make rehabilitation prognosis for stroke patients. At that the following parameters are studied:

  • Amplitude of motor evoked potential (MEP) recorded at cortex stimulation is characterized by the number of undamaged motoneurons in cortex structures.The magnetic stimulator can be successfully used to make rehabilitation prognosis for stroke patients. At that the following parameters are studied:
  • Central motor conduction time (conduction time from cortex to cervical part) reveals the integrity of motor pathways.
  • Amplitude ratio (motor evoked potential/M-wave) is used to assess the excitability of motor cortex.
  • Motor evoked potential facilitation is used when the response is not obtained without facilitation. The obtained response at facilitation and missed one without facilitation can evidence high level of motoneurons and (or) pathways injury. At that the integrity of the given structures is still obvious.

All parameters are recorded separately from right and left sides.

Neuro-MS/D magnetic stimulator has 4 delivery set variants:

Variant 1 — «Diagnostic»
Variant 2 — «Therapeutic»
Variant 3 — «Advanced Therapeutic»
Variant 4 — «Research»

List of Components Variant 1 Variant 2 Variant 3 Variant 4
“Neuro-MS/D” main unit 1 1 1 1
“Neuro-MS/D” extra power supply unit 1 1
“Neuro-MS/D” expansion unit 1
Coil support 1
“Neuro-MS/D” cooling unit 1 1 1
Trolley with custors for magnetic stimulator 1 1 1
FISSO coil holder 1 1
Manfrotto coil holder 1 1
Big ring coil RC-02-150 1
Small ring coil RC-02-100 1
Figure-of-eight coil FEC-02-100 1
Cooled angulated figure-of-eight coil AFEC-02-100-C 1 1 1
HV cable for Neuro-MS/D extra power supply unit 1 1
Hydraulic adapter 2 2 2
Control cable for  Neuro-MS/D cooling unit 1 1
Control cable forNeuro-MS/D cooling and expansion units 1
Equipotential cable 1 2 3
End cap 1 1 1 1
Neuro-MEP Micro (version 2009) 1
Neuro-MS.NET software 1 1 1
Technical manual 1 1 1 1
User manual 1 1 1 1
In 2011, I purchased the first Evidence 3102* from Schreiber&Tholen**, Germany, for my research lab dealing with disease models of peripheral neuropathies, myasthenic syndromes, and of myelopathies in mice and rats. The run-in period was very short because the programs are user-friendly, dependable and adaptable to the special needs in small rodents, the youngest being 8 days old. No EMG machine I ever used before was as powerful as this one. On numerous trips to collaborating labs in the US, Germany and Switzerland I carried this equipment with me. Meanwhile 6 completely established sets are working in most of these collaborating labs. There was no failure ever of the Neurosoft hardware, and in case of minor software problems Schreiber&Tholen provided swift and concise help through the Internet around the globe if needed — again with no precedence in my career in clinical electrophysiology. Even in lab facilities without perfect electromagnetic shielding little if any problems occurred. I highly recommend this equipment to anyone interested in doing clinical neurophysiology in animal models of neurologic disorders

*  Evidence 3102 — Neuro-MEP-Micro 2-channel Ultraportable EMG and NCS System with the Evidence trademark.
**Schreiber&Tholen —  the official distributor of Neurosoft company in Germany, Austria, Switzerland.<

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